Actions of purine analogs: enzyme specificity studies as a basis for interpretation and design.
نویسنده
چکیده
The importance of quantitative studies of the specificities of purine-metabolizing enzymes are discussed. These data not only enable one to make predictions concerning the metabolic disposition and effectiveness of a drug in vivo, but they also help to identify its loci of action. They may also serve as a basis for understanding the selective toxicity of a compound and aid in the design of new antimetabolites.
منابع مشابه
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عنوان ژورنال:
- Cancer research
دوره 29 12 شماره
صفحات -
تاریخ انتشار 1969